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Old before your time: When your body really starts going downhill. Updated. 0. 7: 5. BST, 1. 5 July 2. There's no denying the ticking of a woman's biological clock - but men are not immune, either. French doctors have found that the quality of sperm starts to deteriorate by 3. Here, with the help of leading clinicians, Angela Epstein identifies the ages when different parts of the body start to lose their battle with time. We start with around 1. By 4. 0, we could be losing up to 1. In fact, while the neurons are important, it's actually the deterioration of the gaps between the brain cells that has the biggest impact, says Dr Wojtek Rakowicz, a consultant neurologist at Imperial College Healthcare NHS Trust in London. We all assume grey hair and wrinkles are the first signs of ageing, but some parts of your body are worn out long before you look old. These tiny gaps between the end of one brain nerve cell and another are called synapses. Their job is to ensure the flow of information from one cell to another, and as we age we make fewer. But levels of friendly bacteria in the gut drop significantly after 5. Tom Mac. Donald, professor of immunology at Barts And The London medical school. As a result, we suffer from poor digestion and an increased risk of gut disease. Constipation is more likely as we age, as the flow of digestive juices from the stomach, liver, pancreas and small intestine slows down. Sagging starts properly at 4. Although breast cancer risk increases with age, it's not related to physical changes in the breast. More likely, says Gareth Evans, breast cancer specialist at St Mary's Hospital, Manchester, our cells become damaged with age - as a result, the genes which control cell growth can mutate, causing cancer. The bladder starts to contract suddenly, even when it's not full. Women are more vulnerable to bladder problems as, after the menopause, declining oestrogen levels make tissues in the urethra - the tube through which urine passes - thinner and weaker, reducing bladder support. Bladder capacity in an older adult generally is about half that of a younger person - about two cups in a 3. This causes more frequent trips to the loo, particularly as poor muscle tone means the bladder may not fully empty. This in turn can lead to urinary tract infections. By the age of 4. 0, some people are already experiencing breathlessness. This is partly because the muscles and the rib cage which control breathing stiffen up. It's then harder to work the lungs and also means some air remains in the lungs after breathing out - causing breathlessness. Aged 3. 0, the average man can inhale two pints of air in one breath. By 7. 0, it's down to one. The soft tissues in the voice box (larynx) weaken, affecting the pitch, loudness and quality of the voice. A woman's voice may become huskier and lower in pitch, whereas a man's might become thinner and higher. As we age, the eye's ability to focus deteriorates because the eyes' muscles become weaker, says Andrew Lotery, professor of ophthalmology at the University of Southampton. This is because blood vessels become less elastic, while arteries can harden or become blocked because of fatty deposits forming on the coronary arteries - caused by eating too much saturated fat. The blood supply to the heart is then reduced, resulting in painful angina. Men over 4. 5 and women over 5. A recent study by Lloyds Pharmacy found the average person in the UK has a 'heart age' five years older than their chronological age, probably due to obesity and lack of exercise. He says he can remove ha a liver during surgery and it will grow to the size of a complete liver within three months. If a donor doesn't drink, use drug or suffer from infection, then it is possible to transplant a 7. This is known as benign prostatic hyperplasia and affects half of men over 5. It occurs when the prostate absorbs large amounts of the male sex hormone testosterone, which increases the growth of cells in the prostate. A normal prostate is the size of a walnut, but the condition can increase this to the size of a tangerine. Children's bone growth is rapid - the skeleton takes just two years to renew itself completely. In adults, this can take ten years. Until our mid- 2. But at 3. 5 bone loss begins as part of the natural ageing process. This becomes more rapid in post- menopausal women and can cause the bone- thinning condition osteoporosis. The shrinking in size and density of bones can lead to loss of height. Bones in the back shrivel up or crumble between the vertebrae. We lose two inches in height by the time we're 8. Receding gums - when tissue is lost from gums around the teeth - is common in adults over 4. However, by the time we're 3. Professor Robert Moots. Once adults reach 4. Regular exercise can help prevent this. The condition, known as presbycusis, happens due to a loss of 'hair cells' - tiny sensory cells in the inner ear which pick up sound vibrations and send them to the brain. According to Dr Andrew Wright, a consultant dermatologist with Bradford NHS Trust, as we get older production of collagen - the protein which acts as scaffolding to the skin - slows, and elastin, the substance that enables skin to snap back into place, has less spring and can even break. Dead skin cells don't shed as quickly and turnover of new skin cells may decrease slightly. This causes fine wrinkles and thin, transparent skin - even if the first signs may not appear until our mid- 3. This number can halve later in life. After we turn 6. 0, taste and smell gradually decline, partly as a result of the normal ageing process. This can be accelerated by problems such as polyps in the nasal or sinus cavities. It can also be the cumulative effect of years of smoking. The lining of the womb may become thinner, making it less likely for a fertilised egg to take, and also creating an environment hostile to sperm. Male fertility also starts to drop around this age. Men who wait until their 4. Hair is made in tiny pouches just under the skin's surface, known as follices. A hair normally grows from each follicle for about three years, is then shed, and a new hair grows. However, with male- pattern baldness, changes in levels of testosterone from their early- 3. Each new hair is thinner than the previous one. Eventually, all that remains is a much smaller hair follicle and a thin stump of hair that does not grow out to the skin surface. Most people will have some grey hair by the age of 3. When we are young, our hair is coloured by the pigments produced by cells in the hair follicle known as melanocytes. As we grow older, melanocytes become less active, so less pigment is produced, the colour fades, and grey hairs grow instead. Bette Davis vs Joan Crawford. It was the most notorious cat fight in Hollywood history. In the blue corner, the formidable Bette Davis, and in the red, equally feisty Joan Crawford. Both magnificent actresses on top of their game, both festering with barely concealed hatred for one another. But what could have caused this? Was it mere professional jealousy or something deeper? Liz Kenny reports. A little investigation shows that these two cinematic giants were reduced to duking it out over, what else, a man. Namely, the slightly less legendary, Franchot Tone. Bette starred alongside Franchot in the 1. Dangerous, a part for which she won her first Academy Award. Tone played a handsome architect to Bette’s alcoholic actress and she was soon smitten. Said Bette ” I fell in love with Franchot, professionally and privately. Everything about him reflected his elegance, from his name to his manners.” It’s a pity this debonair actor inspired decades of tit- for- tat cat fighting. Joan Crawford, at that time, was MGM’s reigning sex symbol. Newly divorced and on the prowl, she invited Tone over for dinner, only to greet him naked, in her solarium. Whether it was the nudity or the possibility of free tanning sessions, Franchot was hooked and Joan made sure Bette knew about it. Davis admitted ” He was madly in love with her. They met each day for lunch. I was jealous of course.”With deliberate tactlessness Franchot and Joan (pictured right) proudly announced their engagement. They married in New Jersey as soon as Dangerous wrapped. Their union only lasted til 1. Bette won her second Oscar for Jezebel. The love affair might have bitten the dust but the animosity created would last a lifetime more. Bette looked down on Crawford as a shallow “mannequin” with eyebrows like “African caterpillars” whilst she was a serious, theatre- trained performer. She also called into question Joan’s reputation with the opposite sex, or as she put it “She slept with every male star at MGM, except Lassie.”Crawford was no kinder “Poor Bette,” she tutted “she looks like she’s never had a happy day, or night, in her life.” In 1. Crawford, and her eyebrows, left MGM and signed up with Warner Bros, the studio which just happened to be the home of Ms Davis. Now their professional rivalry was to be cranked up a notch or ten, with both ladies competing for some of the same parts. Crawford won an Academy Award for Mildred Pierce (1. Davis turned down, no doubt adding to her bitterness. Though Bette didn’t do too badly herself, winning two Academy Awards in the course of her career. But it was in 1. 96. The movie was called Whatever Happened to Baby Jane. A chilling story about two former film stars living a lonely existence in their Hollywood mansion, the film saw pasty faced Bette tormenting the bedridden Joan like a hepped up Barbara Cartland. Joan was married to the CEO of Pepsi Cola at that time so Bette made sure she had a Coca Cola machine installed in her dressing room. For a scene in which Bette had to drag Joan across the floor, Joan filled her pockets with rocks. And in those fight scenes, no stunt doubles were necessary. Despite this, the two actresses were described as consummate professionals, always remembering their lines and turning up to the set on time. Even if it was motivated by the chance to give each other a good kicking. Said Bette “The best time I ever had with Joan was when I pushed her down some stairs in Whatever happened to Baby Jane.”Baby Jane enjoyed rave reviews and widespread acclaim, with Davis nominated for a Best Actress Award at the Oscars. Crawford however, was not. Not to take this lying down Crawford came up with a plan. She called all the other actresses nominees offering to accept their awards on the night if they won. Strangely they agreed and so, when Oscar night rolled around, Davis and Crawford found themselves waiting side by side in the wings, with Bette “certain” that the prize was hers. Imagine her horror as the name was announced “. Anne Bancroft for the Miracle Worker!” and Crawford coolly stepped forward to rapturous applause. To deliberately upstage me like that- her behaviour was despicable.”Their claws continued to be out for one another for the remainder of their days, until Joan was the first to pass away from a heart attack. The tragedy did nothing to diminish Davis’ acid tongue; “You should never say bad things about the dead, only good.
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